Bill Wuest

Associate Professor & GRA Distinguished Investigator

Department of Chemistry

Office: Atwood Chemistry Center 557

Phone: 404-712-1143


Additional Contact Information

Additional Websites



  • PhD, University of Pennsylvania, 2008
  • BSc, University of Notre Dame, 2003

Postdoctoral Fellowship

  • NIH NRSA Postdoctoral Fellow at Harvard Medical School, 2008-2011

Honors and Awards

  • GRA Distinguished Investigator, 2017
  • ACS Infectious Diseases Young Investigator Award, 2017
  • ESI Maximizing Investigators Research Award, 2016
  • Thieme Chemistry Award, 2016
  • NSF CAREER Award, 2015
  • Italia-Eire Foundation Distinguished Teacher of the Year, 2014
  • Center for Biofilm Engineering Young Investigator Award, 2013
  • Kaufman Young Investigator Award, 2013
  • NIH NRSA Postdoctoral Fellow, 2010


 Organic Synthesis, Bioorganic Chemistry, Antibiotic Development


  • Solinski, A.E.; Koval, A.B.; Brzozowski, R.S.; Morrison, K.R.; Fraboni, A.J.; Carson, C.E.; Eshraghi A.R.; Zhou, G.; Quivery, R.G.; Voelz, V.A.; Buttaro, B.A.; Wuest. W.M.* “Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms” J. Am. Chem. Soc. 2017 139, 7188. DOI: 10.1021/jacs.7b03879
  • Steele, A.D.; Keohane, C.E.; Knouse, K.W.; Rossiter, S.E.; Williams, S.J.; Wuest, W.M.* “Diverted Total Synthesis of Promysalin Analogs Demonstrates that an Iron-Binding Motif is Responsible for its Narrow-spectrum Antibacterial Activity” J. Am. Chem. Soc. 2016 138, 5833.  DOI: 10.1021/jacs.6b03373
  • Mitchell, M.A.; Iannetta, A.A.; Jennings, M.C.; Fletcher, M.H.; Wuest, W.M.*; Minbiole, K.P.C.* “Scaffold-hopping of Multicationic Amphiphiles Yields Three New Classes of Antimicrobials” ChemBioChem 2015 16, 2299. DOI: 10.1002/cbic.201500381  
  • Steele, A.D.; Knouse, K.W.; Keohane, C.E.; Wuest, W.M.* “Total Synthesis and Biological Evaluation of (-)-Promysalin” J. Am. Chem. Soc. 2015 137, 7314. DOI: 10.1021/jacs.5b04767
  • Jennings, M.C.; Buttaro, B.A.; Minbiole, K.P.C.; Wuest, W.M.* “Bioorganic Investigation of Multicationic Antimicrobials to Combat QAC-Resistant Staphylococcus aureus” ACS Infectious Diseases, 2015 1, 304DOI: 10.1021/acsinfecdis.5b00032