46. Ma, Victor Pui-Yan; Liu, Yang; Blanchfield, Lori; Su, Hanquan; Evavold, Brian; and Salaita, Khalid, “Ratiometric tension probes for mapping receptor forces and clustering at intermembrane junctions” Nano Letters, 2016, in press.

DOI: 10.1021/acs.nanolett.6b01817



45. Yang Liu, Lori Blanchfield, Victor Pui-Yan Ma, Rakieb Andargachew, Kornelia Galior, Zheng Liu, Brian Evavold, Khalid Salaita DNA-based Nanoparticle Tension Sensors Reveal that T-cell Receptors Transmit Defined pN Forces to Their Antigens for Enhanced Fidelity” Proceedings of the National Academy of Sciences, 2016, in press doi:10.1073/pnas.1600163113. [Journal Link]  [Full Text PDF] [Supplementary information]

  1. See also Chemical & Engineering News highlight, May 16th 2016, vol. 94 (2), pg. 12, “T cells tug on antigens”

  2. See also interview explaining work

  3. See also “T cells use handshakes to sort friends from foes” in Emory University Science Commons


44. Ma, P.-Y., Victor; Liu, Yang; Yehl, Kevin; Gailor, Kornelia; Zhang, Yun; and Salaita, Khalid "The Mechanically-induced Catalytic Amplification Reaction for Readout of Receptor-Mediated Cellular Forces", Angewandte Chemie, 2016, in press. [Journal Link] [Full text pdf] [Supplementary Information]

DOI: 10.1002/anie.201600351

  1. See also Nature Methods (June 2016) highlight “PCR for cellular forces” [pdf]

43. Chang, Yuan; Liu, Zheng; Zhang, Yun; Galior, Kornelia; Yang,

Jeffery; Salaita, Khalid; “A General Approach for Generating Fluorescent Probes to Visualize Piconewton Forces at the Cell Surface”, Journal of the American Chemical Society, 2016, in press. [Full text PDF] [Journal link] [Supplementary Information] [SI Movie 1] [SI Movie 2]

DOI: 10.1021/jacs.5b11602

42. Zheng Liu; Yang Liu; Yuan Chang;  Hamid Reza Seyf; Asegun Henry; Alexa L. Mattheyses; Kevin Yehl; Yun Zhang; Zhuangqun Huang; Khalid Salaita; “Nanoscale Optomechanical Actuators for Controlling Mechanotransduction in Living Cells”, Nature Methods, 13, 143–146, 2016. [Journal link] [Full text PDF] [Supplementary information] DOI:10.1038/nmeth.3689

41. Somasuntharam, I.; Yehl, K.; Carroll, S.; Maxwell, J.; Martinez, M.; Pao-Lin Che; Brown, B.; Salaita K.; “Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction”, Biomaterials, 2016, 83, 12–22. [Journal Link] [Full text PDF] [Supplementary Information]  DOI: 

40. Kevin Yehl; Andrew Mugler; Skanda Vivek; Yang Liu; Yun Zhang; Mengzhen Fan; Eric Weeks; Khalid Salaita; “High-speed DNA-based rolling motors powered by RNase H”, Nature Nanotechnology, 2016, 11, 184–190. [Journal link] [Full text PDF] [Supplementary information PDF] DOI: 10.1038/nnano.2015.259

See also Royal Society of Chemistry

See also

See also NanoWerk

See also Emory Science Commons

See also Video

39. Galior, Kornelia; Liu, Yang; Yehl, Kevin; Vivek, Skanda, Salaita, K.; “Titin-based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions”, Nano Letters, 2015, 16 (1), pp 341–348. [Journal Link] [Full text PDF] [NCBI Link] [Supplementary Information] DOI: 10.1021/acs.nanolett.5b03888

See also F1000 prime

38. Daniel Stabley; Thomas Oh; Sanford M. Simon; Alexa L. Mattheyses; Khalid Salaita, “Real-time fluorescence imaging with 20 nm axial resolution”, Nature Communications, 2015, 6, 8307. DOI:10.1038/ncomms9307 [Open Access Journal link] [Open Access Manuscript PDF] [Supplementary Information PDF]

37. Jurchenko, Carol; Salaita, Khalid; “Lighting up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes”, Molecular and Cellular Biology, in press, 2015. [Journal Link] [Free Manuscript PDF]

36. Liu, Y.; Medda, R.; Liu, Z.; Galior, K.; Yehl, K.; Cavalcanti-Adam, A. E.; Spatz, J.; Salaita, K.; “Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of integrin clustering on force transmission”, Nano Letters, 2014, 14(10), 5539-5546.  DOI: 10.1021/nl501912g. [Manuscript PDF] [Supporting Information PDF] [SI movie 1] [SI movie 2] [SI movie 3]


35. Zhang, Y.; Ge, C.; Zhu, C.; Salaita, K.; “DNA-based Digital Tension Probes Reveal Early Cell Adhesion Mechanics at the Single Molecule Level”, Nature Communications, 2014, 5, 5167. [Journal link] [Manuscript PDF] [Supporting Information PDF] [SI movie 1] [SI movie 2] [SI movie 3] [SI movie 4].

See research feature in Nature Reviews Molecular and Cell Biology

See research feature in Nature Methods

See research feature in C&E News

See research feature in Emory eScienceCommons

34. Jurchenko, Carol; Chang, Yuan; Narui, Yoshie; Zhang, Yun; Salaita, Khalid; “Integrin-generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions", Biophysical Journal, 2014, 106(7), 1436-1446. [Journal link] [Manuscript pdf] [Supporting Information] [SI movie 1] [SI movie 2].

See highlight in April 7th, 2014 issue of C&E News:

33. Zheng, Weiwei; Liu, Yang; West, Ana; Schuler, Erin; Yehl, Kevin; Dyer, R.; Kindt, James; Salaita, Khalid; “Quantum dots encapsulated within phospholipid membranes: phase-dependent structure, photostability, and site-selective functionalization", Journal of the American Chemical Society, 2014, 136(5), 1992–1999. [Journal link] [Manuscript pdf]  [SI movie 1] [Supporting information]

32. Boopathy, A. V.; Che, P. L.; Somasuntharam I., Fiore V. F.; Cabigas, E. B.; Ban, K.; Brown M. E.; Narui, Y.; Barker T. H.; Yoon, Y.; Salaita, K.; García, A. J.; Davis, M. E.; The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation, Biomaterials, 2014, 35(28), 8103-8112.

[Journal link] [Manuscript pdf]

31. Jiang, T.; Xu, C.; Liu, Y.; Liu, Z.; Wall S. J.; Zuo, X.; Lian, T.; Salaita, K.; Ni, C.; Pochan, D.; Conticello, V., P.; “Structurally Defined Nano-scale Sheets from Self-Assembly of Collagen-Mimetic PeptidesJournal of the American Chemical Society, 2014, 136(11), 4300-4308. [Journal link] [manuscript pdf] [supporting information]

30. Narui, Y.; Salaita, K. “Membrane Tethered Delta Activates Notch and Reveals a Role for Spatio-Mechanical Regulation of the Signaling Pathway”, Biophysical Journal, 2013, 105(12), 2655-2665.

[Journal link] [Manuscript PDF]

[supporting information] [SI movie 1] [SI movie 2] [manuscript and SI pdf]

29. Liu, Y.; Yehl, K.; Narui, Y.; Salaita, K. Tension Sensing Nanoparticles for Mechano-imaging at the Living Non-living Interface Journal of the American Chemical Society, 2013, 135(14), 5320–5323.

[link] [pdf] [supporting information] [movie 1] [movie 2]

28. Stabley, D.; Retterer, S.; Marshall, S.; Salaita, K. Manipulating the Lateral Diffusion of Surface-Anchored EGF Demonstrates that Receptor Clustering Modulates Phosphorylation Levels, Integrative Biology, 2013, 5, 659-668. [link] [pdf][supporting information] [movie 1] [movie 2] [movie 3]

See also: Back cover art integrative biology

27. Yehl, K.; Joshi, J.P.; Greene, B.L.; Dyer, R. B.; Nahta, R.; Salaita, K. Catalytic Deoxyribozyme-Modified Nanoparticles for RNAi-Independent Gene Regulation, ACS Nano, 2012, 6(10), 9150–9157. [link] [pdf] [supporting information]

26. Chan, C.; Salaita, K. The Molecular Boat: A Hands-on Experiment to Demonstrate the Forces Applied to Self-Assembled Monolayers at Interfaces, Journal of Chemical Education, 2012, 89(12), 1547–1550. [link] [pdf] [supporting information]

See also: [Coverart]

25. Narui, Y.; Salaita, K. Dip-pen Nanolithography of Optically Transparent Cationic Polymers to Manipulate Spatial Organization of Proteolipid Membranes, Chemical Science, 2012, 3, 794-799. [link] [pdf] [supplementary information]

24. Stabley, D.; Schumacher, C.; Marshall, S.; Salaita, K. Visualizing Mechanical Tension Across Membrane Receptors with a Fluorescent Sensor, Nature Methods, 2012, 9, 64-67. [link] [pdf] [supplementary information] [youtube]

See interview in Nature Methods [nmeth.1816.pdf]

See also C&E news highlight: [C&ENews] [C&E News video]

23. Laroui, H.; Yan, Y.; Narui, Y.; Ingersoll, S. A.; Ayyadurai, S.; Charania, M. A.; Zhou, F.; Salaita, K.; Sitaraman, S.V.; Merlin, D.;L-Ala-g-D-Glu-meso-DAP interacts directly with the leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing the phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its interaction with nucleotide-binding oligomerization domain 1, Journal of Biological Chemistry2011, 286, 31003-31013 [link] [pdf] 

22. Laroui, H.; Wilson, D.S.; Dalmasso G.; Salaita, K.; Murthy, N.; Sitaraman, S.V.; Merlin, D.; Nanomedicine in GI, Am. J. Physiol. Gastrointest. Liver. Physiol., 2011, 300(3), G371-G383, [link] [pdf]

Prior Publications

21. Nair, P. N.; Salaita, K.; Petit, R. P.; Groves, J. T.; Investigating the Role of Receptor Organization Using Geometrically Patterned Lipid Membranes, Nature Protocols, 2011, 6, 523-539. [link] [pdf] 

20. Salaita, K.; Groves, J.T.; Roles of the cytoskeleton in regulating EphA2 signals, Communicative & Integrative Biology, 2010, 3(5), 454-457. [link] [pdf]

19. Salaita, K.*; Nair, P.N.*; Petit, R.; Das, D.; Gray, J.W.; Groves, J.T.; Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2, Science, 2010, 327(5971), 1380-1385. [pdf] [link] [Science] [nature materials] [Nature Reviews Molecular Cell Biology] [Science Signaling]

18. Salaita, K.; Amarnath, A.; Higgins, T. B.; Mirkin, C. A.; The Effects of Organic Vapor on Alkanethiol Deposition Via Dip-Pen Nanolithography. Scanning, 2010, 32 (1); 9-14. [link]

17. Clack, N. C.*; Salaita, K.*; Groves, J. T.; Electrostatic Imaging of DNA Microarrays Using Charged Particles. Nature Biotechnology, 2008, 26(7); 825-830. [link] [Chemical and Engineering News] [Nature Materials]

16. Salaita, K.; Wang, Y.; Vega, R. A.; Mirkin, C. A.; Applications of Dip-Pen Nanolithography. Nature Nanotechnology, 2007, 2; 145-155. [link]

15. Salaita, K.; Lee, S.-W.; Ginger, D. S; Mirkin, C. A.; DPN-Generated Nanostructures as Positive Resists For Preparing Lithographic Masters or Hole Arrays. Nano Lett. 2006, (6)11; 2493-2498. [link]

14. Salaita, K.*; Wang, Y.*; Fragala, J.; Vega, R. A.; Liu, C.; Mirkin, C. A.; Massively Parallel Dip-Pen Nanolithography with 55,000 Two-Dimensional Arrays. Angew. Chem. Int. Edit., 2006, 45(43); 7220-7223. (Cover Article). [link] [Nature] [Science] [Chemical and Engineering News]

13. Sun, P.; Zong, H.; Salaita, K.; Ketter, J. B.; Hoffman, B. M.; Mirkin, C. A.; Probing Electrochemical Potential Versus Surface Distance by Molecular Orientation. J. Phys. Chem. B. 2006, 110(37); 18151-18153. [link]    

12. Khoshbin, M. S.; Ovchinnikov, M. V., Salaita, K., Mirkin, C. A., Stern, C. L., Zakharov, L. N. Rheingold, A. L.; Metallomacrocycles Incorporating Cofacially Aligned Diimide Units. Chem. Asian J., 2006, 1(5); 686-692. (Cover Article) [link] 

11.Vega, R. A.; Salaita, K.; Kakkessery, J. J.; Mirkin, C. A.; Nanopatterns of Biological Molecules. In Nanobiotechnology II: Concept, Applications and Perspectives. Wiley-VCH, Weinheim, Germany, 2007, Chapter 13, 235-262. [link]

10. Lee, S. W.; Oh, B. K.; Sanedrin, R. G.; Salaita, K.; Mirkin, C. A. Biologically Active Protein Nanoarrays Generated Using Parallel Dip-Pen Nanolithography. Adv. Mat. 2006, 18, 1133-1136. [link]

9. Salaita, K. Fabrication of Colloidal Nanostructures from Nanolithographically Defined Templates. Interface, 2005, 14(4); 58-59.

8. Salaita, K.; Lee, S.-W.; Wang, X.; Huang, L.; Dellinger, T. M.; Liu, C.; Mirkin, C. A. Sub-100nm, Centimeter-Scale, Parallel Dip-Pen Nanolithography. Small 2005, 1(10); 940-945. [link]

7. Salaita, K.; Amarnath, A.; Maspoch, D.; Higgins, T. B.; Mirkin, C. A.Spontaneous “Phase Separation” of Patterned Binary Alkanethiol Mixtures. J. Am. Chem. Soc. 2005, 127(32); 11283-11287. [link]

6. Vega, R. A.; Maspoch D.; Salaita, K.; Mirkin C. A. Nanoarrays of Single Virus Particles. Angew. Chem. Int. Edit. 2005, 44(37); 6013-6015. [link] 

5. Liu, X.; Zhang, Y.; Goswami, D. K.; Okasinski, J. S.; Salaita, K.; Sun, P.; Bedzyk, M. B.; Mirkin, C. A. The Controlled Evolution of a Single Crystal. Science 2005, 307; 1763-1766. [link]   

4. Vesper, B. J.; Salaita K.; Zong, Z.; Mirkin, C. A.; Barrett, A. G.; Hoffman, B. M. Surface-Bound Porphyrazines: Controlling Reduction Potentials of Self-Assembled Monolayers Through Molecular Proximity/Orientation to a Metal Surface. J. Am. Chem. Soc. 2004, 126(50); 16653-16658. [link] [Science]

3. Xu, X.-H. N.; Huang, S.; Brownlow, W.; Salaita, K.; Jeffers, R. B. Size and Temperature Dependence of Surface Plasmon Absorption of Gold Nanoparticles Induced by Tris(2,2'-bipyridine)ruthenium(II). J. Phys. Chem. B.2004, 108(40); 15543-15551. [link]     

2. Zhang, Y.*; Salaita, K.*; Lim. J.-H.; Lee, K.-B.; Mirkin, C. A. A Massively Parallel Electrochemical Approach to the Miniaturization of Organic Micro- and Nanostructures on Surfaces. Langmuir  2004, 20(3); 962-968. [link]

1. Zhang, Y.; Salaita, K.; Lim, J.-H.; Mirkin, C. A. Electrochemical Whittling of Organic Nanostructures. Nano Lett. 2002, 2(12);1389-1392. [link]