45. Yang Liu, Lori Blanchfield, Victor Pui-Yan Ma, Rakieb Andargachew, Kornelia Galior, Zheng Liu, Brian Evavold, Khalid Salaita DNA-based Nanoparticle Tension Sensors Reveal that T-cell Receptors Transmit Defined pN Forces to Their Antigens for Enhanced Fidelity” Proceedings of the National Academy of Sciences, 2016, in press.

44. Ma, P.-Y., Victor; Liu, Yang; Yehl, Kevin; Gailor, Kornelia; Zhang, Yun; and Salaita, Khalid "The Mechanically-induced Catalytic Amplification Reaction for Readout of Receptor-Mediated Cellular Forces", Angewandte Chemie, 2016, in press. [Journal Link] [Full text pdf] [Supplementary Information]

DOI: 10.1002/anie.201600351

43. Chang, Yuan; Liu, Zheng; Zhang, Yun; Galior, Kornelia; Yang,

Jeffery; Salaita, Khalid; “A General Approach for Generating Fluorescent Probes to Visualize Piconewton Forces at the Cell Surface”, Journal of the American Chemical Society, 2016, in press. [Full text PDF] [Journal link] [Supplementary Information] [SI Movie 1] [SI Movie 2]

DOI: 10.1021/jacs.5b11602

42. Zheng Liu; Yang Liu; Yuan Chang;  Hamid Reza Seyf; Asegun Henry; Alexa L. Mattheyses; Kevin Yehl; Yun Zhang; Zhuangqun Huang; Khalid Salaita; “Nanoscale Optomechanical Actuators for Controlling Mechanotransduction in Living Cells”, Nature Methods, 13, 143–146, 2016. [Journal link] [Full text PDF] [Supplementary information] DOI:10.1038/nmeth.3689

41. Somasuntharam, I.; Yehl, K.; Carroll, S.; Maxwell, J.; Martinez, M.; Pao-Lin Che; Brown, B.; Salaita K.; “Knockdown of TNF-α by DNAzyme gold nanoparticles as an anti-inflammatory therapy for myocardial infarction”, Biomaterials, 2016, 83, 12–22. [Journal Link] [Full text PDF] [Supplementary Information]  DOI: 

40. Kevin Yehl; Andrew Mugler; Skanda Vivek; Yang Liu; Yun Zhang; Mengzhen Fan; Eric Weeks; Khalid Salaita; “High-speed DNA-based rolling motors powered by RNase H”, Nature Nanotechnology, 2016, 11, 184–190. [Journal link] [Full text PDF] [Supplementary information PDF] DOI: 10.1038/nnano.2015.259

See also Royal Society of Chemistry

See also

See also NanoWerk

See also Emory Science Commons

See also Video

39. Galior, Kornelia; Liu, Yang; Yehl, Kevin; Vivek, Skanda, Salaita, K.; “Titin-based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions”, Nano Letters, 2015, 16 (1), pp 341–348. [Journal Link] [Full text PDF] [NCBI Link] [Supplementary Information] DOI: 10.1021/acs.nanolett.5b03888

See also F1000 prime

38. Daniel Stabley; Thomas Oh; Sanford M. Simon; Alexa L. Mattheyses; Khalid Salaita, “Real-time fluorescence imaging with 20 nm axial resolution”, Nature Communications, 2015, 6, 8307. DOI:10.1038/ncomms9307 [Open Access Journal link] [Open Access Manuscript PDF] [Supplementary Information PDF]

37. Jurchenko, Carol; Salaita, Khalid; “Lighting up the Force: Investigating Mechanisms of Mechanotransduction Using Fluorescent Tension Probes”, Molecular and Cellular Biology, in press, 2015. [Journal Link] [Free Manuscript PDF]

36. Liu, Y.; Medda, R.; Liu, Z.; Galior, K.; Yehl, K.; Cavalcanti-Adam, A. E.; Spatz, J.; Salaita, K.; “Nanoparticle Tension Probes Patterned at the Nanoscale: Impact of integrin clustering on force transmission”, Nano Letters, 2014, 14(10), 5539-5546.  DOI: 10.1021/nl501912g. [Manuscript PDF] [Supporting Information PDF] [SI movie 1] [SI movie 2] [SI movie 3]


35. Zhang, Y.; Ge, C.; Zhu, C.; Salaita, K.; “DNA-based Digital Tension Probes Reveal Early Cell Adhesion Mechanics at the Single Molecule Level”, Nature Communications, 2014, 5, 5167. [Journal link] [Manuscript PDF] [Supporting Information PDF] [SI movie 1] [SI movie 2] [SI movie 3] [SI movie 4].

See research feature in Nature Reviews Molecular and Cell Biology

See research feature in Nature Methods

See research feature in C&E News

See research feature in Emory eScienceCommons

34. Jurchenko, Carol; Chang, Yuan; Narui, Yoshie; Zhang, Yun; Salaita, Khalid; “Integrin-generated Forces Lead to Streptavidin-Biotin Unbinding in Cellular Adhesions", Biophysical Journal, 2014, 106(7), 1436-1446. [Journal link] [Manuscript pdf] [Supporting Information] [SI movie 1] [SI movie 2].

See highlight in April 7th, 2014 issue of C&E News:

33. Zheng, Weiwei; Liu, Yang; West, Ana; Schuler, Erin; Yehl, Kevin; Dyer, R.; Kindt, James; Salaita, Khalid; “Quantum dots encapsulated within phospholipid membranes: phase-dependent structure, photostability, and site-selective functionalization", Journal of the American Chemical Society, 2014, 136(5), 1992–1999. [Journal link] [Manuscript pdf]  [SI movie 1] [Supporting information]

32. Boopathy, A. V.; Che, P. L.; Somasuntharam I., Fiore V. F.; Cabigas, E. B.; Ban, K.; Brown M. E.; Narui, Y.; Barker T. H.; Yoon, Y.; Salaita, K.; García, A. J.; Davis, M. E.; The modulation of cardiac progenitor cell function by hydrogel-dependent Notch1 activation, Biomaterials, 2014, 35(28), 8103-8112.

[Journal link] [Manuscript pdf]

31. Jiang, T.; Xu, C.; Liu, Y.; Liu, Z.; Wall S. J.; Zuo, X.; Lian, T.; Salaita, K.; Ni, C.; Pochan, D.; Conticello, V., P.; “Structurally Defined Nano-scale Sheets from Self-Assembly of Collagen-Mimetic PeptidesJournal of the American Chemical Society, 2014, 136(11), 4300-4308. [Journal link] [manuscript pdf] [supporting information]

30. Narui, Y.; Salaita, K. “Membrane Tethered Delta Activates Notch and Reveals a Role for Spatio-Mechanical Regulation of the Signaling Pathway”, Biophysical Journal, 2013, 105(12), 2655-2665.

[Journal link] [Manuscript PDF]

[supporting information] [SI movie 1] [SI movie 2] [manuscript and SI pdf]

29. Liu, Y.; Yehl, K.; Narui, Y.; Salaita, K. Tension Sensing Nanoparticles for Mechano-imaging at the Living Non-living Interface Journal of the American Chemical Society, 2013, 135(14), 5320–5323.

[link] [pdf] [supporting information] [movie 1] [movie 2]

28. Stabley, D.; Retterer, S.; Marshall, S.; Salaita, K. Manipulating the Lateral Diffusion of Surface-Anchored EGF Demonstrates that Receptor Clustering Modulates Phosphorylation Levels, Integrative Biology, 2013, 5, 659-668. [link] [pdf][supporting information] [movie 1] [movie 2] [movie 3]

See also: Back cover art integrative biology

27. Yehl, K.; Joshi, J.P.; Greene, B.L.; Dyer, R. B.; Nahta, R.; Salaita, K. Catalytic Deoxyribozyme-Modified Nanoparticles for RNAi-Independent Gene Regulation, ACS Nano, 2012, 6(10), 9150–9157. [link] [pdf] [supporting information]

26. Chan, C.; Salaita, K. The Molecular Boat: A Hands-on Experiment to Demonstrate the Forces Applied to Self-Assembled Monolayers at Interfaces, Journal of Chemical Education, 2012, 89(12), 1547–1550. [link] [pdf] [supporting information]

See also: [Coverart]

25. Narui, Y.; Salaita, K. Dip-pen Nanolithography of Optically Transparent Cationic Polymers to Manipulate Spatial Organization of Proteolipid Membranes, Chemical Science, 2012, 3, 794-799. [link] [pdf] [supplementary information]

24. Stabley, D.; Schumacher, C.; Marshall, S.; Salaita, K. Visualizing Mechanical Tension Across Membrane Receptors with a Fluorescent Sensor, Nature Methods, 2012, 9, 64-67. [link] [pdf] [supplementary information] [youtube]

See interview in Nature Methods [nmeth.1816.pdf]

See also C&E news highlight: [C&ENews] [C&E News video]

23. Laroui, H.; Yan, Y.; Narui, Y.; Ingersoll, S. A.; Ayyadurai, S.; Charania, M. A.; Zhou, F.; Salaita, K.; Sitaraman, S.V.; Merlin, D.;L-Ala-g-D-Glu-meso-DAP interacts directly with the leucine-rich region domain of nucleotide-binding oligomerization domain 1, increasing the phosphorylation activity of receptor-interacting serine/threonine-protein kinase 2 and its interaction with nucleotide-binding oligomerization domain 1, Journal of Biological Chemistry2011, 286, 31003-31013 [link] [pdf] 

22. Laroui, H.; Wilson, D.S.; Dalmasso G.; Salaita, K.; Murthy, N.; Sitaraman, S.V.; Merlin, D.; Nanomedicine in GI, Am. J. Physiol. Gastrointest. Liver. Physiol., 2011, 300(3), G371-G383, [link] [pdf]

Prior Publications

21. Nair, P. N.; Salaita, K.; Petit, R. P.; Groves, J. T.; Investigating the Role of Receptor Organization Using Geometrically Patterned Lipid Membranes, Nature Protocols, 2011, 6, 523-539. [link] [pdf] 

20. Salaita, K.; Groves, J.T.; Roles of the cytoskeleton in regulating EphA2 signals, Communicative & Integrative Biology, 2010, 3(5), 454-457. [link] [pdf]

19. Salaita, K.*; Nair, P.N.*; Petit, R.; Das, D.; Gray, J.W.; Groves, J.T.; Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2, Science, 2010, 327(5971), 1380-1385. [pdf] [link] [Science] [nature materials] [Nature Reviews Molecular Cell Biology] [Science Signaling]

18. Salaita, K.; Amarnath, A.; Higgins, T. B.; Mirkin, C. A.; The Effects of Organic Vapor on Alkanethiol Deposition Via Dip-Pen Nanolithography. Scanning, 2010, 32 (1); 9-14. [link]

17. Clack, N. C.*; Salaita, K.*; Groves, J. T.; Electrostatic Imaging of DNA Microarrays Using Charged Particles. Nature Biotechnology, 2008, 26(7); 825-830. [link] [Chemical and Engineering News] [Nature Materials]

16. Salaita, K.; Wang, Y.; Vega, R. A.; Mirkin, C. A.; Applications of Dip-Pen Nanolithography. Nature Nanotechnology, 2007, 2; 145-155. [link]

15. Salaita, K.; Lee, S.-W.; Ginger, D. S; Mirkin, C. A.; DPN-Generated Nanostructures as Positive Resists For Preparing Lithographic Masters or Hole Arrays. Nano Lett. 2006, (6)11; 2493-2498. [link]

14. Salaita, K.*; Wang, Y.*; Fragala, J.; Vega, R. A.; Liu, C.; Mirkin, C. A.; Massively Parallel Dip-Pen Nanolithography with 55,000 Two-Dimensional Arrays. Angew. Chem. Int. Edit., 2006, 45(43); 7220-7223. (Cover Article). [link] [Nature] [Science] [Chemical and Engineering News]

13. Sun, P.; Zong, H.; Salaita, K.; Ketter, J. B.; Hoffman, B. M.; Mirkin, C. A.; Probing Electrochemical Potential Versus Surface Distance by Molecular Orientation. J. Phys. Chem. B. 2006, 110(37); 18151-18153. [link]    

12. Khoshbin, M. S.; Ovchinnikov, M. V., Salaita, K., Mirkin, C. A., Stern, C. L., Zakharov, L. N. Rheingold, A. L.; Metallomacrocycles Incorporating Cofacially Aligned Diimide Units. Chem. Asian J., 2006, 1(5); 686-692. (Cover Article) [link] 

11.Vega, R. A.; Salaita, K.; Kakkessery, J. J.; Mirkin, C. A.; Nanopatterns of Biological Molecules. In Nanobiotechnology II: Concept, Applications and Perspectives. Wiley-VCH, Weinheim, Germany, 2007, Chapter 13, 235-262. [link]

10. Lee, S. W.; Oh, B. K.; Sanedrin, R. G.; Salaita, K.; Mirkin, C. A. Biologically Active Protein Nanoarrays Generated Using Parallel Dip-Pen Nanolithography. Adv. Mat. 2006, 18, 1133-1136. [link]

9. Salaita, K. Fabrication of Colloidal Nanostructures from Nanolithographically Defined Templates. Interface, 2005, 14(4); 58-59.

8. Salaita, K.; Lee, S.-W.; Wang, X.; Huang, L.; Dellinger, T. M.; Liu, C.; Mirkin, C. A. Sub-100nm, Centimeter-Scale, Parallel Dip-Pen Nanolithography. Small 2005, 1(10); 940-945. [link]

7. Salaita, K.; Amarnath, A.; Maspoch, D.; Higgins, T. B.; Mirkin, C. A.Spontaneous “Phase Separation” of Patterned Binary Alkanethiol Mixtures. J. Am. Chem. Soc. 2005, 127(32); 11283-11287. [link]

6. Vega, R. A.; Maspoch D.; Salaita, K.; Mirkin C. A. Nanoarrays of Single Virus Particles. Angew. Chem. Int. Edit. 2005, 44(37); 6013-6015. [link] 

5. Liu, X.; Zhang, Y.; Goswami, D. K.; Okasinski, J. S.; Salaita, K.; Sun, P.; Bedzyk, M. B.; Mirkin, C. A. The Controlled Evolution of a Single Crystal. Science 2005, 307; 1763-1766. [link]   

4. Vesper, B. J.; Salaita K.; Zong, Z.; Mirkin, C. A.; Barrett, A. G.; Hoffman, B. M. Surface-Bound Porphyrazines: Controlling Reduction Potentials of Self-Assembled Monolayers Through Molecular Proximity/Orientation to a Metal Surface. J. Am. Chem. Soc. 2004, 126(50); 16653-16658. [link] [Science]

3. Xu, X.-H. N.; Huang, S.; Brownlow, W.; Salaita, K.; Jeffers, R. B. Size and Temperature Dependence of Surface Plasmon Absorption of Gold Nanoparticles Induced by Tris(2,2'-bipyridine)ruthenium(II). J. Phys. Chem. B.2004, 108(40); 15543-15551. [link]     

2. Zhang, Y.*; Salaita, K.*; Lim. J.-H.; Lee, K.-B.; Mirkin, C. A. A Massively Parallel Electrochemical Approach to the Miniaturization of Organic Micro- and Nanostructures on Surfaces. Langmuir  2004, 20(3); 962-968. [link]

1. Zhang, Y.; Salaita, K.; Lim, J.-H.; Mirkin, C. A. Electrochemical Whittling of Organic Nanostructures. Nano Lett. 2002, 2(12);1389-1392. [link]